abstract：:The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted targeting doctors in the specialty most frequently diagnosing and treating PDB patients in Japan. First, the literature ...

journal_title：Journal of bone and mineral metabolism

authors： Hashimoto J,Ohno I,Nakatsuka K,Yoshimura N,Takata S,Zamma M,Yabe H,Abe S,Terada M,Yoh K,Fukunaga M,Cooper C,Morii H,Yoshikawa H,Japanese Committee on Clinical Guidelines of Diagnosis and Treatment of Paget's Disease of Bone o

更新日期：2006-01-01 00:00:00

abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...

journal_title：Journal of bone and mineral metabolism

authors： Lee IT,Sheu WH,Tu ST,Kuo SW,Pei D

更新日期：2006-01-01 00:00:00

abstract：:Osteotropic growth factors play an important role in bone metabolism. Nevertheless, knowledge about their expression in relation to distraction osteogenesis remains limited. The aim of the present study was to determine the expression of growth hormone (GH), growth hormone receptor (GHR), insulin-like growth factor I ...

journal_title：Journal of bone and mineral metabolism

authors： Theyse LF,Oosterlaken-Dijksterhuis MA,van Doorn J,Terlou M,Mol JA,Voorhout G,Hazewinkel HA

更新日期：2006-01-01 00:00:00

abstract：:The prevalence and pattern of joint involvement in radiographic hand osteoarthritis (OA) have been reported in Western populations, but similar data are lacking for Japanese. We examined this issue in 551 Japanese women aged > or = 40 years. Radiographs were obtained of both hands and graded according to the Kellgren-...

journal_title：Journal of bone and mineral metabolism

authors： Toba N,Sakai A,Aoyagi K,Yoshida S,Honda S,Nakamura T

更新日期：2006-01-01 00:00:00

abstract：:Data from retrospective and prospective observational and case-control studies suggest that activity is associated with reduced fracture risk, but consistently replicated bias may be responsible for this desired endpoint. Exercise during growth is likely to build a larger and stronger skeleton. However, cessation of e...

journal_title：Journal of bone and mineral metabolism

authors： Seeman E

更新日期：2005-01-01 00:00:00

abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

journal_title：Journal of bone and mineral metabolism

authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

更新日期：2005-01-01 00:00:00

abstract：:Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodi...

journal_title：Journal of bone and mineral metabolism

authors： Carbone LD,Barrow KD,Bush AJ,Boatright MD,Michelson JA,Pitts KA,Pintea VN,Kang AH,Watsky MA

更新日期：2005-01-01 00:00:00

abstract：:Syndecans are single-pass integral membrane components that serve as co-receptors for growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We review here previous studies from our groups on syndecan-3 biology and function in the growth plates of developing long bones in chick an...

journal_title：Journal of bone and mineral metabolism

authors： Pacifici M,Shimo T,Gentili C,Kirsch T,Freeman TA,Enomoto-Iwamoto M,Iwamoto M,Koyama E

更新日期：2005-01-01 00:00:00

abstract：:Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...

journal_title：Journal of bone and mineral metabolism

authors： Wong SY,Lau EM,Li M,Chung T,Sham A,Woo J

更新日期：2005-01-01 00:00:00

abstract：:Variation in drug response to hormone replacement therapy (HRT) may reflect genetic heterogeneity in the estrogen-related genes, possibly including estrogen receptor alpha (ERalpha) gene. However, only a few association studies of the drug response to HRT have been reported, focusing mainly on the intronic polymorphis...

journal_title：Journal of bone and mineral metabolism

authors： Yim CH,Choi JT,Choi HA,Kang YS,Moon IG,Yoon HK,Han IK,Kang DH,Han KO

更新日期：2005-01-01 00:00:00

abstract：:Three-dimensional (3D) alteration of trabecular microarchitecture is a risk factor for vertebral fractures. Histomorphometry allows microarchitectural analysis of bone, but the necessity to perform a transiliac bone biopsy limits its use in large series of patients. X-Ray films are commonly used in routine practice an...

journal_title：Journal of bone and mineral metabolism

authors： Chappard D,Guggenbuhl P,Legrand E,Baslé MF,Audran M

更新日期：2005-01-01 00:00:00

abstract：:There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...

journal_title：Journal of bone and mineral metabolism

authors： Kanaji A,Higashi M,Namisato M,Ando K,Nakagawa M,Yato Y,Ichinose H,Sakamaki T,Yamada H

更新日期：2005-01-01 00:00:00

abstract：:A cell line of murine osteogenic progenitor cells, Kusa, was established from femoral bone marrow stromal cells with other types of mesenchymal progenitor cells. We characterized two sublines of Kusa (Kusa-A1 and Kusa-O) from several aspects, including the use of an expression profiling system, a cDNA microarray. The ...

journal_title：Journal of bone and mineral metabolism

authors： Kawashima N,Shindo K,Sakamoto K,Kondo H,Umezawa A,Kasugai S,Perbal B,Suda H,Takagi M,Katsube K

更新日期：2005-01-01 00:00:00

abstract：:In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RF...

journal_title：Journal of bone and mineral metabolism

authors： Lei SF,Liu YZ,Deng FY,Li YM,Li MX,Deng HW

更新日期：2005-01-01 00:00:00

abstract：:We investigated the enhancement of new bone |formation elicited ectopically by recombinant human bone morphogenetic protein-2 (rhBMP-2), using parathyroid hormone (PTH) and a phosphodiesterase inhibitor (PDEi), pentoxifylline (PTX), in an animal model. Collagen sponge sheet discs containing rhBMP were implanted onto t...

journal_title：Journal of bone and mineral metabolism

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Tsutsumimoto T,Otsuru S,Takaoka K

更新日期：2004-01-01 00:00:00

abstract：:Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testostero...

journal_title：Journal of bone and mineral metabolism

authors： Rhee EJ,Oh KW,Lee WY,Kim SW,Oh ES,Baek KH,Kang MI,Park CY,Choi MG,Yoo HJ,Park SW

更新日期：2004-01-01 00:00:00

abstract：:Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident...

journal_title：Journal of bone and mineral metabolism

authors： Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo H

更新日期：2004-01-01 00:00:00

abstract：:It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

journal_title：Journal of bone and mineral metabolism

authors： Iba K,Takada J,Yamashita T

更新日期：2004-01-01 00:00:00

abstract：:This study was designed to investigate whether biochemical markers of bone resorption and formation could be determined in the serum and urine of marmosets (Callithrix jacchus), using standard laboratory chemistry methods and commercially available human kits. Consequently, the findings from this study will indicate w...

journal_title：Journal of bone and mineral metabolism

authors： Angeliewa A,Budde M,Schlachter M,Hoyle NR,Bauss F

更新日期：2004-01-01 00:00:00

abstract：:In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindI...

journal_title：Journal of bone and mineral metabolism

authors： Mo XY,Cao CK,Xu FH,Liu MY,Li MX,Qin YJ,Zhou Q,Zhang YY,Deng HW

更新日期：2004-01-01 00:00:00

abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

journal_title：Journal of bone and mineral metabolism

authors： Hishiya A,Watanabe K

更新日期：2004-01-01 00:00:00

abstract：:Quantitative ultrasound (QUS) is used for prediction for risks of osteoporotic fractures at various skeletal sites, irrespective of weight-bearing or non-weight-bearing skeletons. In the current study, we investigated the correlation between calcaneal QUS measurements (BUA, VOS, and Soundness) and volumetric trabecula...

journal_title：Journal of bone and mineral metabolism

authors： Hung VW,Qin L,Au SK,Choy WY,Leung KS,Leung PC,Cheng JC

更新日期：2004-01-01 00:00:00

abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...

journal_title：Journal of bone and mineral metabolism

authors： Ito M,Akai E,Izuka M,Segawa H,Kuwahata M,Miyamoto K

更新日期：2004-01-01 00:00:00

abstract：:In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...

journal_title：Journal of bone and mineral metabolism

authors： Bonofiglio D,Garofalo C,Catalano S,Marsico S,Aquila S,Andò S

更新日期：2004-01-01 00:00:00

abstract：:There are many factors that increase the risk of osteoporosis, including smoking, malnutrition, vitamin D deficiency, hypogonadism, limited physical activity due to chronic disease, and corticosteroid therapy in chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Karadag F,Cildag O,Yurekli Y,Gurgey O

更新日期：2003-01-01 00:00:00

abstract：:Notch is a transmembrane protein involved in cell fate determination. In the present study, we observed temporally and spatially restricted expression of Notch1 in developing cartilage. Notch1 was localized starting from the mesenchymal condensation stage of embryonic mouse forelimbs. Interestingly, although localizat...

journal_title：Journal of bone and mineral metabolism

authors： Watanabe N,Tezuka Y,Matsuno K,Miyatani S,Morimura N,Yasuda M,Fujimaki R,Kuroda K,Hiraki Y,Hozumi N,Tezuka K

更新日期：2003-01-01 00:00:00

abstract：:Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...

journal_title：Journal of bone and mineral metabolism

authors： Chailurkit LO,Jongjaroenprasert W,Rungbunnapun S,Ongphiphadhanakul B,Sae-tung S,Rajatanavin R

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone minera...

journal_title：Journal of bone and mineral metabolism

authors： Nanjo Y,Morio Y,Nagashima H,Hagino H,Teshima R

更新日期：2003-01-01 00:00:00

abstract：:Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...

journal_title：Journal of bone and mineral metabolism

authors： Miki T,Nakatsuka K,Naka H,Kitatani K,Saito S,Masaki H,Tomiyoshi Y,Morii H,Nishizawa Y

更新日期：2003-01-01 00:00:00

abstract：:The effects of basic fibroblast growth factor (bFGF) on osteogenic differentiation in-vivo were investigated using a rat bone marrow ablation model. bFGF was infused directly into rat femora for 6 days after bone marrow ablation. The contralateral femur was infused with vehicle only and used as control. Bone formation...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka H,Wakisaka A,Ogasa H,Kawai S,Liang CT

更新日期：2003-01-01 00:00:00

abstract：:Gastrectomy-evoked osteopenia in the femoral metaphysis of rats can be prevented by the consumption of fructooligosaccharides (FOS). We examined the effect of FOS on the femoral neck. Twenty-eight 5-week-old male Sprague-Dawley rats were divided into two groups, sham-operated (SH) and gastrectomized (GX). One week aft...

journal_title：Journal of bone and mineral metabolism

authors： Hirama Y,Morohashi T,Sano T,Maki K,Ohta A,Sakai N,Yamada S,Sasa R

更新日期：2003-01-01 00:00:00

abstract：:We have been using hormone replacement therapy (HRT) as the treatment of choice for menopausal symptoms and osteoporosis. Estrogen increases bone mineral density (BMD) for 2 or 3 years, and only maintains BMD thereafter. In the present study, we investigated whether BMD improved with HRT in combination with vitamin K(...

journal_title：Journal of bone and mineral metabolism

authors： Hidaka T,Hasegawa T,Fujimura M,Sakai M,Saito S

更新日期：2002-01-01 00:00:00

abstract：:Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia). We aimed to investigate whether such osteopathic changes occurred in rats with chronic constriction injury (CCI) of the sciatic nerve. A CCI of the sciatic nerve was established in a unilat...

journal_title：Journal of bone and mineral metabolism

authors： Suyama H,Moriwaki K,Niida S,Maehara Y,Kawamoto M,Yuge O

更新日期：2002-01-01 00:00:00

abstract：:Leptin has been proposed to be a key molecule involved in energy regulation. Based on the generally acknowledged concept that a heavier person has a higher bone density, leptin is thought to be potentially involved in bone metabolism. Serum leptin, various bone markers, and bone mineral density (BMD) were studied in 5...

journal_title：Journal of bone and mineral metabolism

authors： Yoneda T,Maruyama Y,Uji Y,Motomiya Y,Hashiguchi Y,Miura M,Kitajima I,Maruyama I

更新日期：2001-01-01 00:00:00

abstract：:Based on the relationship between bone strength, trabecular skeletal structure, and bone mineral density (BMD), structure parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra of elderly persons. The trabecular bone pattern of each bone block was b...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka T,Sakurai T,Kashima I

更新日期：2001-01-01 00:00:00

abstract：:McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia. However, it remains unclear whether a humoral factor is associated with the cause of hypophosphatemia. We isolated cells with mutations of the Gsalpha gene from fibrous bone dysplasia tissues of two MAS patients (MAS cells). Severe combined i...

journal_title：Journal of bone and mineral metabolism

authors： Yamamoto T,Miyamoto KI,Ozono K,Taketani Y,Katai K,Miyauchi A,Shima M,Yoshikawa H,Yoh K,Takeda E,Okada S

更新日期：2001-01-01 00:00:00

abstract：:Cleidocranial dysplasia (CCD) is an autosomal dominant disorder due to mutations in runt-related gene 2 (RUNX2)/polyomavirus enhancer-binding protein 2alphaA (PEBP2alphaA)/core-binding factor A1 (CBFA1)/acute myeloid leukemia 3 (AML3). To investigate the RUNX2 mutations in a Japanese patient with classic CCD, we analy...

journal_title：Journal of bone and mineral metabolism

authors： Goseki-Sone M,Orimo H,Watanabe A,Hamatani R,Yokozeki M,Ohyama K,Kuroda T,Watanabe H,Miyazaki H,Shimada T,Oida S

更新日期：2001-01-01 00:00:00

abstract：:The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

journal_title：Journal of bone and mineral metabolism

authors： Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

更新日期：2001-01-01 00:00:00

abstract：:Bone marrow stromal cells have been considered to play an important role in osteoclast differentiation. However, the interaction of these cells in vivo has not been clearly demonstrated. To clarify this, we examined the distribution of alkaline phosphatase (ALPase) and tartrate-resistant acid phosphatase (TRAPase) act...

journal_title：Journal of bone and mineral metabolism

authors： Kondo Y,Irie K,Ikegame M,Ejiri S,Hanada K,Ozawa H

更新日期：2001-01-01 00:00:00

abstract：:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, an...

journal_title：Journal of bone and mineral metabolism

authors： Yaoita H,Orimo H,Shirai Y,Shimada T

更新日期：2000-01-01 00:00:00